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Pacemaker channels in the sinoatrial node generate the sinus rhythm and regulate the heart rate In an Italian family affected by sinus bradycardia, a mutation was identified in the αsubunit ofNonetheless it is important for the EM physician to be aware of which patients are likely to require permanent pacemaker at a later dateNov 28, 05 · Initial treatment of any patient with bradycardia should focus on support of airway and breathing (Box 2) Provide supplementary oxygen, place the patient on a monitor, evaluate blood pressure and oxyhemoglobin saturation, and establish intravenous (IV) access Evaluating And Managing Bradycardia Sciencedirect Sinus bradycardia treatment without pacemaker